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Synthesis 2007(14): 2208-2214  
DOI: 10.1055/s-2007-983764
PAPER
© Georg Thieme Verlag Stuttgart · New York

Synthesis of the 4,10-Dihydro-3H-pyridazino[1,6-b]isoquinolin-10-one System by a Furan Recyclization Reaction

Alexander V. Butin*a, Artem S. Dmitrieva, Olga N. Kostyukovaa, Vladimir T. Abaevb, Igor V. Trushkovc
a Research Institute of Heterocyclic Compounds Chemistry, Kuban State University of Technology, Moskovskaya St. 2, Krasnodar 350072, Russian Federation
Fax: +7(861)2596592; e-Mail: alexander_butin@mail.ru; e-Mail: av_butin@yahoo.com;
b North-Ossetian State University, Vatutina St. 46, Vladikavkaz 362025, Russian Federation
c Department of Chemistry, M.V. Lomonosov Moscow State University, Leninskie Gory 1/3, Moscow 119992, Russian Federation
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Publication History

Received 27 April 2007
Publication Date:
03 July 2007 (online)

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Abstract

The novel 4,10-dihydro-3H-pyridazino[1,6-b]isoquinolin-10-one heterocyclic system was synthesized by acid-catalyzed recyclization of 2-(difurylmethyl)benzohydrazides as well as by recyclization of (2-carboxyaryl)difurylmethanes to isocoumarins followed by the reaction with hydrazine hydrate.

Key words

furans - ring opening - ring closure - fused-ring system - pyridazino[1,6-b]isoquinolinone

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