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Synthesis 2007(17): 2653-2659  
DOI: 10.1055/s-2007-983816
PAPER
© Georg Thieme Verlag Stuttgart · New York

N-Methylimidazole as a Promising Catalyst for the Aza-Michael Addition Reaction of N-Heterocycles

Bo Kai Liu, Qi Wu, Xue Qi Qian, De Shui Lv, Xian Fu Lin*
Department of Chemistry, Zhejiang University, Hangzhou 310027, P.R. of China
Fax: +86(571)87952618; e-Mail: llc123@zju.edu.cn;
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Publication History

Received 25 April 2007
Publication Date:
24 July 2007 (online)

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Abstract

N-Methylimidazole has been shown to be a promising catalyst for aza-Michael reactions. Various N-heterocycles were introduced­ to α,β-unsaturated carbonyl compounds employing N-meth­ylimidazole (0.05 equiv) in a highly efficient, rapid and high yielding synthesis of N-heterocyclic derivatives.

Key words

N-methylimidazole - Michael additions - nucleophiles - heterocycles - α,β-unsaturated compounds