Planta Med 2007; 73 - P_091
DOI: 10.1055/s-2007-986873

Vismiaturucallone, a new Antimalarial tetracyclic triterpene from Vismia laurentii (Clusiaceae)

DT Noungoue 1, S Ngom 3, J Ngoupayo 1, M Chaabi 3, BL Ndjakou 1, S Ngouela 1, C Antheaume 3, FF Boyom 2, J Gut 4, PJ Rosenthal 4, A Lobstein 3, E Tsamo 1
  • 1Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon
  • 2Department of Biochemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812 Yaoundé, Cameroon
  • 3Laboratory of Pharmacognosy, LC1 UMR 7175, Faculty of Pharmacy, Strasbourg, France
  • 4Division of Infectious Diseases, Department of Medicine, University of California, United States

In the framework of our interest in antimalarial natural products from Clusiaceae family [1,2], the apolar extract of the stem bark of Vismia laurentii showed good antimalarial activity (IC50=4.6µg/ml). Thus, the isolation of its constituents led to the identification of a new tetracyclic triterpene, (20-ethylnortirucalla-7,24-dien-3-one) vismiaturucallone (1) (Fig.1) along with eight known compounds namely 3-geranyloxyemodin, vismiaquinone A (3), vismiaquinone B, bivismiaquinone, epifriedelinol, betulinic acid, tirucalla-7,24-dien-3-one, and stigmasta-7,22-dien-3-ol. Compounds (1) and (3) showed antiplasmodial activity against chloroquine-resistant W2 strain of Plasmodium falciparum with IC50 of 1.17µM and 1.42µM, respectively.

Fig.1

References: [1] Ngouela, S. et al. (2005) Nat Prod Res 19(7):685–8. [2] Ngouela, S. et al. (2006) Phytochemistry 67(3):302–6.