Abstract
In search of novel gastroprotective agents, mangiferin, a naturally occurring glucosylxanthone
from Mangifera indica L. (Anacardiaceae), was evaluated in mice on gastric injury induced by ethanol and
indomethacin. The effects of mangiferin on gastric mucosal damage were assessed by
determination of changes in mean gastric lesion area or ulcer score in mice and on
gastric secretory volume and total acidity in 4-h pylorus-ligated rats. Mangiferin
(3, 10 and 30 mg/kg, p. o.) significantly attenuated the gastric damage induced by ethanol by 30, 35, and 63
%, and of indomethacin by 22, 23 and 57 %, respectively. N-Acetylcysteine (750 mg/kg, i. p.) and lansoprazole (30 mg/kg, p. o.) used as positive controls in these ulcerogenic models resulted in 50 % and 76 %
suppression of gastric injury, respectively. In 4-h pylorus-ligated rats, intraduodenally
applied mangiferin (30 mg/kg) caused significant diminutions in gastric secretory
volume and total acidity. In addition, like N-acetylcysteine, a donor of sulfhydryls, mangiferin effectively prevented the ethanol-associated
depletion of gastric mucosal non-protein sulfhydryl content in mice, suggesting an
antioxidant action. These findings provide evidence that mangiferin affords gastroprotection
against gastric injury induced by ethanol and indomethacin most possibly through the
antisecretory and antioxidant mechanisms of action.
Key words
Anacardiaceae -
Mangifera indica
- mangiferin - glucosylxanthone - gastroprotection
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V. S. N. Rao
Departamento de Fisiologia e Farmacologia
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