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A Novel Complementary Synthesis of Multisubstituted Cyclopentenones via [3+2] Cyclization
J. Barluenga*, P. Barrio, L. Riesgo, L. A. López, M. Tomás
Universidad de Oviedo, Spain
23 January 2008 (online)
The formal [3+2]-cycloaddition reaction between an alkenyl-Fischer carbene complex and internal alkynes was found to offer a straightforward access to trisubstituted cyclopent-2-enones with a novel substitution pattern that cannot be easily accessed by conventional methods.