Synfacts 2008(2): 0188-0188  
DOI: 10.1055/s-2007-992471
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart · New York

A Novel Complementary Synthesis of Multisubstituted Cyclopentenones via [3+2] Cyclization

Contributor(s): Paul Knochel, Tobias Thaler
J. Barluenga*, P. Barrio, L. Riesgo, L. A. López, M. Tomás
Universidad de Oviedo, Spain
Further Information

Publication History

Publication Date:
23 January 2008 (online)


The formal [3+2]-cycloaddition reaction between an alkenyl-Fischer carbene complex and internal alkynes was found to offer a straightforward access to trisubstituted cyclopent-2-enones with a novel substitution pattern that cannot be easily accessed by conventional methods.