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Formal Synthesis of (-)-Diazonamide A
C.-M. Cheung, F. W. Goldberg, P. Magnus*, C. J. Russell, R. Turnbull, V. Lynch
University of Texas at Austin, USA
23 January 2008 (online)
Diazonamide A, a metabolite of the ascidian Diazona angulata, displays potent in vitro activity against human colon cancer. A very easy O-aryl to C-aryl migration of O-tyrosine ethers B and C was used to generate the C10 quaternary stereogenic center in D and E.