Planta Med 2008; 74(3): 267-272
DOI: 10.1055/s-2008-1034311
Natural Products Chemistry
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Isolation and Characterization of New Cannabis Constituents from a High Potency Variety

Mohamed M. Radwan1 , Samir A. Ross1 , 2 , Desmond Slade1 , Safwat A. Ahmed1 , Fazila Zulfiqar1 , Mahmoud A. ElSohly1 , 3
  • 1National Center for Natural Products Research, School of Pharmacy, The University of Mississippi, University, MS, USA
  • 2Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, MS, USA
  • 3Department of Pharmaceutics, School of Pharmacy, The University of Mississippi, University, MS, USA
Further Information

Publication History

Received: October 16, 2007 Revised: December 10, 2007

Accepted: January 16, 2008

Publication Date:
18 February 2008 (online)

Abstract

Phytochemical investigation of a high potency variety of Cannabis sativa L. resulted in the isolation of six new metabolites, (±)-6,7-trans-epoxycannabigerolic acid (2), (±)-6,7-cis-epoxycannabigerolic acid (3), (±)-6,7-cis-epoxycannabigerol (4), (±)-6,7-trans-epoxycannabigerol (5), 5′-methyl-4-pentylbiphenyl-2,2′,6-triol (7), and 7-methoxycannabispirone (8), along with seven known compounds namely, cannabigerolic acid (1), 5′-methoxycannabigerolic acid (6), cannabispirone (9), β-cannabispiranol (10), dehydrocannabifuran (11), cannflavin B (12) and cannabigerol (13). The antimicrobial as well as the antileishmanial activities were investigated.

Abbreviations

CBG:cannabigerol

CBD:cannabidiol

FID:flame ionization detector

Δ9-THC:Δ9-tetrahydrocannabinol

VLC:vacuum liquid chromatography

References

Dr. Samir A. Ross

National Center for Natural Products Research

School of Pharmacy

The University of Mississippi

University

MS 38677

USA

Phone: +1-662-915-1031

Fax: +1-662-915-7989

Email: sross@olemiss.edu

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