Synfacts 2008(3): 0219-0219  
DOI: 10.1055/s-2008-1042657
Synthesis of Natural Products and Potential Drugs
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Quadrangularin A and Pallidol

Contributor(s): Philip Kocienski, Stewart Eccles
S. A. Snyder*, A. L. Zografos, Y. Lin
Columbia University, New York, USA
Further Information

Publication History

Publication Date:
21 February 2008 (online)


Resveratrol-based oligomers are produced combinatorially by plants in response to environmental stress. Snyder and co-workers report that the core structure A can be transformed to every member of the family by simply altering reagents and reaction conditions. Pallidol, quadrangularin, ampelopsins D and F, paucifloral F, and hemsleyanol E were all synthesized by related cationic cyclization cascades.