Subscribe to RSS
Addition of Arylboronic Acids to N-Boc Imines Generated in situ
H. Nakagawa, J. C. Rech, R. W. Sindelar, J. A. Ellman*
University of California, Berkeley, USA
21 February 2008 (online)
This is a nice report for the enantioselective addition of arylboronic acids to N-Boc imines. The strong point of this paper is that the imines are generated in situ from easily prepared α-carbamoyl sulfones and the product contains the useful Boc-protected imine. High enantioselectivities are obtained for a variety of arylboronic acid nucleophiles.