Synfacts 2008(3): 0280-0280  
DOI: 10.1055/s-2008-1042700
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Diastereoselective Cascade Reactions: Cyclization-Cross-Coupling

Contributor(s): Mark Lautens, Valentina Aureggi
V. B. Phapale, E. Buñuel, M. García-Iglesias, D. J. Cárdenas*
Universidad Autonoma de Madrid, Spain
Further Information

Publication History

Publication Date:
21 February 2008 (online)


Metal-catalyzed C(sp3)-C(sp3) cross-coupling reactions represent an important process in modern organic chemistry. An efficient nickel-catalyzed cross-coupling reaction of alkyl iodides with alkyl zinc bromides is reported. The synthesis of more complex molecules is achieved in moderate to good yields with excellent diaste­reoselectivities.