Subscribe to RSS
Diastereoselective Cascade Reactions: Cyclization-Cross-Coupling
V. B. Phapale, E. Buñuel, M. García-Iglesias, D. J. Cárdenas*
Universidad Autonoma de Madrid, Spain
21 February 2008 (online)
Metal-catalyzed C(sp3)-C(sp3) cross-coupling reactions represent an important process in modern organic chemistry. An efficient nickel-catalyzed cross-coupling reaction of alkyl iodides with alkyl zinc bromides is reported. The synthesis of more complex molecules is achieved in moderate to good yields with excellent diastereoselectivities.