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Mixed Lithium-Zinc Species for the Deprotonation of Five-Membered Aromatic Heterocycles
J.-M. L’Helgoual’ch, A. Seggio, F. Chevallier, M. Yonehara, E. Jeanneau, M. Uchiyama*, F. Mongin*
Université de Rennes 1 and Université Claude Bernard Lyon 1, Villeurbanne, France; RIKEN, Wako-shi, Japan
21 February 2008 (online)
The article describes a novel synergetic approach towards the chemoselective deprotonation of five-membered heterocycles. Hereby, (TMP)2Zn (0.5 equiv) and LiTMP (0.5 equiv) are prepared in situ from LiTMP and ZnCl2 .TMEDA which are employed in a 3:1 ratio.