Synlett 2008(7): 949-957  
DOI: 10.1055/s-2008-1042907
ACCOUNT
© Georg Thieme Verlag Stuttgart · New York

Recent Advances in Direct Arylation via Palladium-Catalyzed Aromatic C-H Activation

Bi-Jie Li, Shang-Dong Yang, Zhang-Jie Shi*
Beijing National Laboratory of Molecular Sciences and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Green Chemistry Center, Peking University, Beijing 100871, P. R. of China
Fax: +86(10)62760890; e-Mail: zshi@pku.edu.cn;
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Publikationsverlauf

Received 22 October 2007
Publikationsdatum:
11. März 2008 (online)

Abstract

Highly selective arylation catalyzed by palladium and directed by the acetamino group provides an efficient and practical protocol for constructing unique biaryl scaffolds, which could be further transformed into different structural units found in a range of natural products.

1 Introduction

2 Highly Regioselective Halogenation

3 Highly Regioselective Arylation

3.1 With Arylboronic Acids

3.2 With Trialkoxyarylsilanes

3.3 With Simple Arenes

3.4 Further Transformations

4 Conclusion