Synthesis of 4-, 5- and 6-Benzoylated 7-Azaindoles

Christelle Pillard; Carine Ekambomé Bassène; Franck Suzenet; Gérald Guillaumet

doi:10.1055/s-2008-1067103

PAPER

Synthesis of 4-, 5- and 6-Benzoylated 7-Azaindoles

Christelle Pillard, Carine Ekambomé Bassène, Franck Suzenet*, Gérald Guillaumet
Institut de Chimie Organique et Analytique (I.C.O.A.), UMR-CNRS 6005, FR CNRS 2708, Université d"Orléans, Rue de Chartres, BP 6759, 45067 Orléans Cedex 02, France
Fax: +33(2)38417281; e-Mail: gerald.guillaumet@univ-orleans.fr;

Abstract

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Abstract

Efficient syntheses of 4-, 5- and 6-benzoyl-7-azaindoles are described. Two strategies were developed: i) formation of 4-lithio and 5-lithio-7-azaindole and reaction with aldehydes and ii) organomagnesium addition to 6-cyano-7-azaindole. Both methods should allow the introduction of a diverse range of acyl substituents.

Key words

7-azaindole - acylation - 6-cyano-7-azaindole - fused-ring system - lithium-halogen exchange

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References

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