Synthesis 2008(15): 2337-2346  
DOI: 10.1055/s-2008-1067152
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Thiazolo[4,5-d]pyridines

Viktor O. Iaroshenkoa,c, Dmitriy M. Volochnyuk*b,f, Nadiya V. Kryvokhyzhad, Aleksander Martylogac,f, Dmitri V. Sevenarde, Ulrich Grotha, Jörg Branda, Alexander N. Chernegab, Alexander N. Shivanyukc,f, Andrei A. Tolmachevc
a Fachbereich Chemie, Universität Konstanz, Fach M-720, Universitätsstraße 10, 78457 Konstanz, Germany
b Institute of Organic Chemistry, National Academy of Sciences of Ukraine, Murmanska 5, 02094 Kyiv-94, Ukraine
Fax: +380(44)5373253; e-Mail: D.Volochnyuk@enamine.net;
c National Taras Shevchenko University, 62 Volodymyrska St., 01033 Kyiv-33, Ukraine
d Department of Chemistry, University of Glasgow, University Avenue, Glasgow G12 8QQ, UK
e Hansa Fine Chemicals GmbH, BITZ, Fahrenheitstraße 1, 28359 Bremen, Germany
f ‘Enamine Ltd.’, 23 A. Matrosova St., 01103 Kyiv, Ukraine
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Publikationsverlauf

Received 24 February 2008
Publikationsdatum:
18. Juni 2008 (online)

Abstract

The reaction of 2-aminothiazol-4(5H)-iminium salts with various 1,3-CCC-dielectrophiles was investigated. As a result, a set of diverse thiazolo[4,5-d]pyridines were obtained. The scope and limitation of the approach is described.

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Sheldrick G. M. SHELXTL PLUS. PC Version. A system of computer programs for the determination of crystal structure from X-ray diffraction data. Rev.5.1. 1998.

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Crystallographic data (excluding structure factors) for the structures reported in this paper have been deposited with the Cambridge Crystallographic Data Center as supplementary publications CCDC 677236 and 677237 and can be obtained free of charge on application to CCDC, 12 Union Road, Cambridge CB2 1EZ, UK; fax: +44(1223)336033; e-mail: deposit@ccdc.cam.ac.uk.