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Synfacts 2008(5): 0503-0503  
DOI: 10.1055/s-2008-1072647
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag Stuttgart · New York

Ru(II)-Catalyzed Highly Enantioselective Hydrogenation of Acyl Silanes

Contributor(s): Hisashi Yamamoto, Marina Naodovic
N. Arai, K. Suzuki, S. Sugizaki, H. Sorimachi, T. Ohkuma*
Hokkaido University, Sapporo, Japan
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Publikationsdatum:
23. April 2008 (online)

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Significance

Enantiopure functionalized silanes represent a group of highly useful organometallic precursors for the synthesis of several groups of molecules. From that aspect, the catalytic system described is a very valuable catalyst. Tol-binap/pica Ru(II) efficiently catalyzes the reduction of aromatic, aliphatic and α,β-unsaturated acyl silanes under mild conditions and high substrate/catalyst ratio.