Planta Med 2008; 74(7): 754-759
DOI: 10.1055/s-2008-1074536
Natural Product Chemistry
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Diarylheptanoids from the Pericarps of Walnuts (Juglans regia)

Jun-Xi Liu1 , Duo-Long Di1 , Xiao-Ning Wei1 , Yin Han2
  • 1Key Laboratory for Natural Medicine of Gansu Province, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, P.R. China
  • 2School of Life Science, Lanzhou University, Lanzhou, P.R. China
Further Information

Publication History

Received: November 19, 2007 Revised: March 19, 2008

Accepted: March 31, 2008

Publication Date:
21 May 2008 (online)

Abstract

Two new diarylheptanoids, juglanin A (1) and B (2), together with 15 known compounds, were isolated from the extract of the seed husks of walnuts (Juglans regia L.). The structures of 1 and 2 were elucidated by various spectroscopic methods including intensive 2D-NMR techniques, HR-ESI-MS, and X-ray single-crystal diffraction analysis, and the cytotoxic activities of 1, 2, and 10 against human hepatoma (Hep G2) cells was reported.

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Prof. Duo-Long Di

Lanzhou Institute of Chemical Physics

Chinese Academy of Sciences

Lanzhou 730000

People’s Republic of China

Phone: +86-931-496-8248

Fax: +86-931-827-7088

Email: didl@lzb.ac.cn