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DOI: 10.1055/s-2008-1074536
© Georg Thieme Verlag KG Stuttgart · New York
Cytotoxic Diarylheptanoids from the Pericarps of Walnuts (Juglans regia)
Publication History
Received: November 19, 2007
Revised: March 19, 2008
Accepted: March 31, 2008
Publication Date:
21 May 2008 (online)
Abstract
Two new diarylheptanoids, juglanin A (1) and B (2), together with 15 known compounds, were isolated from the extract of the seed husks of walnuts (Juglans regia L.). The structures of 1 and 2 were elucidated by various spectroscopic methods including intensive 2D-NMR techniques, HR-ESI-MS, and X-ray single-crystal diffraction analysis, and the cytotoxic activities of 1, 2, and 10 against human hepatoma (Hep G2) cells was reported.
Key words
Juglans regia L. - Juglandaceae - diarylheptanoids - cytotoxic activity
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Prof. Duo-Long Di
Lanzhou Institute of Chemical Physics
Chinese Academy of Sciences
Lanzhou 730000
People’s Republic of China
Phone: +86-931-496-8248
Fax: +86-931-827-7088
Email: didl@lzb.ac.cn
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