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Planta Med 1980; 40(10): 212-217
DOI: 10.1055/s-2008-1074961
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Mycoflora of Crude Drugs

Estimation of Mould Contaminations and their Toxicity1 J. Lutomski, B. Kędzia
  • Institute of Medicinal Plants, Poznari, Poland
1 Dedicated to Prof. Dr. Drs. h.c. KURT MOTHES on the occasion of his 80th birthday
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Publikationsdatum:
29. April 2008 (online)

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Abstract

Two hundred and fortysix crude drug samples were examined for their mould contamination. The number of moulds per g, less than 100, from 100 to 10000 and more than 10000 were found in 10 %, 66 % and 24 % respectively of the crude drug samples examined.

Two hundred and eight mould strains of 23 genera were isolated from 50 crude drug samples. The genera Aspergillus (75), Penicillium (28), Mucor, Rhizopus and Thamnidium (50) were predominant among the moulds found. The strains of Aspergillus and Penicillium were examined for their ability to produce aflatoxin B1, ochratoxin A and sterigmatocistin. Two strains of the genus Aspergillus were toxinogenic: one strain isolated from one sample of Fol. Salviae and one strain isolated from one sample of Rh. Tormentillae produced 0,2 μg/ml and 1,5 μg/ ml aflatoxin B1, respectively. No strains producing other mycotoxins were found.

A rare toxinogenic mould contamination of the crude drugs examined, as well as a low level of aflatoxin B, production in them, do not seem to be a risk of patient mycotoxicosis as a result of ingestion of those crude drugs.

Key Word Index

Crude Drugs - Contamination - Mycotoxins.