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Synfacts 2008(8): 0808-0808
DOI: 10.1055/s-2008-1077944
DOI: 10.1055/s-2008-1077944
Synthesis of Heterocycles
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Trifluoromethyltriazoles via 1,3-Dipolar Cycloaddition
C.-T. Zhang, X. Zhang, F.-L. Qing*
Donghua University and Shanghai Institute of Organic Chemistry, P. R. of China
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
23. Juli 2008 (online)
Significance
Reported here is a convenient method for the regioselective synthesis of 4-trifluoromethyl-1,4,5-trisubstituted-1,2,3-triazoles by 1,3-dipolar cycloaddition of trifluoromethyl alkynols with aliphatic azides under ruthenium-catalyzed conditions. The authors state that the regioselectivity appears to be controlled by the polarity effects. Perhaps due to unavailability of additional alkynols, the scope of the method was insufficiently investigated.