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Synfacts 2008(8): 0815-0815
DOI: 10.1055/s-2008-1078578
DOI: 10.1055/s-2008-1078578
Synthesis of Materials and Unnatural Products
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of Furans, Pyrroles and Thiophenes from a Single Substrate
G. Yin, Z. Wang, A. Chen, M. Gao, A. Wu*, Y. Pan*
Central China Normal University, Wuhan and Zhejiang University, Hangzhou, P. R. of China
Further Information
Publication History
Publication Date:
23 July 2008 (online)
Significance
Five-membered heterocycles are important structural units found in all fields of organic chemistry. The authors demonstrate an sp³-hybridized carbon-carbon bond-forming reaction to produce 1,4-diketones that were further elaborated to methylthio-substituted furans, pyrroles and thiophenes via the Paal-Knorr cyclization in good yields.