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Planta Med 2019; 85(06): 444-452
DOI: 10.1055/a-0828-9831
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Cytotoxic Prenylated Xanthones from the Leaves of Garcinia bracteata

Bao-Jun Zhang   *
1   School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, Peopleʼs Republic of China
2   Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, Peopleʼs Republic of China
3   Department of Pharmacy, ShangHai PuTuo District People Hospital, Shanghai, Peopleʼs Republic of China
,
Wen-Wei Fu   *
1   School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, Peopleʼs Republic of China
2   Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, Peopleʼs Republic of China
,
Rong Wu
1   School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, Peopleʼs Republic of China
2   Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, Peopleʼs Republic of China
,
Jin-Ling Yang
1   School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, Peopleʼs Republic of China
2   Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, Peopleʼs Republic of China
,
Cai-Yun Yao
4   Guangxi Botanical Garden of Medicinal Plants, Nanning, Peopleʼs Republic of China
,
Bing-Xiong Yan
4   Guangxi Botanical Garden of Medicinal Plants, Nanning, Peopleʼs Republic of China
,
Hong-Sheng Tan
1   School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, Peopleʼs Republic of China
2   Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, Peopleʼs Republic of China
,
Chang-Wu Zheng
1   School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, Peopleʼs Republic of China
2   Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, Peopleʼs Republic of China
,
Zhi-Jun Song
4   Guangxi Botanical Garden of Medicinal Plants, Nanning, Peopleʼs Republic of China
,
Hong-Xi Xu
1   School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, Peopleʼs Republic of China
2   Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai, Peopleʼs Republic of China
› Author Affiliations
Further Information

Publication History

received 28 June 2018
revised 23 December 2018

accepted 27 December 2018

Publication Date:
16 January 2019 (online)

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Abstract

Six new prenylated xanthones (1–6) and seventeen known xanthones were isolated from extracts of Garcinia bracteata leaves. Their structures were determined by extensive NMR and MS spectroscopic data analysis. The inhibitory activities of the isolates were assayed on HeLa, A549, PC-3, HT-29, and WPMY-1 cell lines. Compounds 1 and 15–17 showed moderate inhibitory effects on tumor cell growth, with IC50s ranging from 3.7 to 14.7 µM.

Key words

Garcinia bracteata - Clusiaceae - prenylated xanthones - cytotoxicity

* These two authors contributed equally to this work.


Supporting Information

 

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