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Planta Med 2019; 85(09/10): 701-707
DOI: 10.1055/a-0855-4051
Biological and Pharmacological Activity
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Four New Cytotoxic Arborinane-Type Triterpenes from the Endolichenic Fungus Myrothecium inundatum

Buddha Bahadur Basnet   *
1   State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China
2   International College, University of Chinese Academy of Sciences, Beijing, China
,
Li Liu   *
4   Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China
,
Baosong Chen   *
1   State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China
3   Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China
,
Yerlan Melsuly Suleimen
5   Institute of Applied Chemistry, Chemistry Department of L. N. Gumilyov Eurasian National University, Astana, Republic of Kazakhstan
,
Haiyang Yu
6   Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China
,
Shouyu Guo
1   State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China
,
Li Bao
1   State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China
3   Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China
,
Jinwei Ren
1   State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China
3   Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China
,
Hongwei Liu
1   State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing, China
3   Savaid Medical School, University of Chinese Academy of Sciences, Beijing, China
› Author Affiliations
Further Information

Publication History

received 14 November 2018
revised 21 January 2019

accepted 07 February 2019

Publication Date:
19 February 2019 (online)

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Abstract

Two new arborinane-type triterpenes, myrotheols A (1) and B (2), two new arborinane-type glycosides, myrothesides C (3) and D (4), together with four known diterpenes (5 – 8) were isolated from the ethyl acetate extract of the endolichenic fungus Myrothecium inundatum. The structures of new compounds 1 – 4 were elucidated by NMR and MS analyses. The absolute configuration of 1 was assigned by a single-crystal X-ray diffraction experiment. Compounds 3 and 4 represent the first two natural 4-O-methyl-α-D-mannosides. Compounds 1 – 8 exhibited cytotoxicity against K562 and RKO human cancer cell lines.

Key words

endolichenic fungi - Myrothecium inundatum - Stachybotryaceae - arborinane-type - riterpenes - diterpenes - cytotoxicity

* These authors contributed equally to this work.


Supporting Information

    The 1H, 13C, and 2D NMR spectra of the new compounds 1 – 4 as well as the column graphs of cytotoxicity are available as Supporting Information.

  • Supporting Information
 

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