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Planta Med 2020; 86(17): 1298-1303
DOI: 10.1055/a-1209-3501
Biological and Pharmacological Activity
Original Papers

New Alkenylresorcinols with Cytotoxic and Antimicrobial Activities from the Leaves of Embelia schimperi

Tatiana Arlette M. Togue
1   Faculty of Science, Department of Chemistry, University of Dschang, Dschang, Cameroon
,
Blanche Laure Ndontsa
1   Faculty of Science, Department of Chemistry, University of Dschang, Dschang, Cameroon
,
Gabin Thierry M. Bitchagno
1   Faculty of Science, Department of Chemistry, University of Dschang, Dschang, Cameroon
2   Institute of Organic Chemistry, Johannes Gutenberg-University of Mainz, Mainz, Germany
,
Anja Schüffler
3   Institut für Biotechnologie und Wirkstoff-Forschung gGmbH (IBWF), Kaiserslautern, Germany
,
Till Opatz
2   Institute of Organic Chemistry, Johannes Gutenberg-University of Mainz, Mainz, Germany
,
Pierre Tane   †
1   Faculty of Science, Department of Chemistry, University of Dschang, Dschang, Cameroon
,
Mathieu Tene 
1   Faculty of Science, Department of Chemistry, University of Dschang, Dschang, Cameroon
› Author AffiliationsSupported by: German Academic Exchange Service (DAAD) 57381410
Supported by: International Foundation for Science and Organization for the Prohibition of Chemical Weapons F5543
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Abstract

A phytochemical study of the methanol extract of the leaves of Embelia schimperi resulted in the isolation of three new alkenylresorcinols, 1 – 3, together with the known analogs 4 – 7. Their structures were established by a combination of spectroscopic techniques. Compounds 1 – 7 exhibited moderate cytotoxic activity against human cervical cancer cells HeLa-S3 and more pronounced antimicrobial properties towards bacteria and filamentous fungi. The present study falls into an ongoing research project on the characterization of bioactive phenolic lipids from plants of the family Primulaceae.

Key words

Embelia schimperi - Primulaceae - structure elucidation - alkenylresorcinol - cytotoxicity - antimicrobial activity

† Deceased.


Supporting Information

    IR, UV, HR-ESI-MS, and 1D and 2D NMR spectra of compounds 1 – 3 (Figs. 1S – 25S and 27S – 35S) and the ESIMS spectrum of the dimethyldisulfide derivative of 3 (Fig. 26S) are available as Supporting information.

  • Supporting Information


Publication History

Received: 22 March 2020

Accepted after revision: 21 June 2020

Article published online:
29 July 2020

© 2020. Thieme. All rights reserved.

Georg Thieme Verlag KG
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