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Synthesis 2021; 53(13): 2293-2303
DOI: 10.1055/a-1395-4788
DOI: 10.1055/a-1395-4788
paper
Efficient Monofluoroalkylation of Thiophenols or Phenols with α-Bromo-α-Fluoroketones under Mild Conditions
Authors
We are grateful for financial support from the National Natural Science Foundation of China (Grant Nos. 21672151 and 21602136).
Abstract
An efficient nucleophilic substitution reaction between α-bromo-α-fluoroketones and thiophenols or phenols is reported for the synthesis of α-fluoro-β-ketosulfides or α-fluoro-β-ketone ethers in yields ranging from 78–93%. This method exhibits good functional group tolerance and a broad scope of nucleophilic substrates, including natural phenolic compounds.
Key words
monofluoroalkyltion - nucleophilic substitution - α-bromo-α-fluoroketones - α-fluoro-β-ketosulfides - α-fluoro-β-ketone ethersSupporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-1395-4788.
- Supporting Information (PDF)
Publication History
Received: 28 December 2020
Accepted after revision: 18 February 2021
Accepted Manuscript online:
18 February 2021
Article published online:
04 March 2021
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