I₂-DMSO-Promoted Direct Synthesis of Substituted Imidazoles from Styrenes and Benzylamines under Solvent-Free Conditions

Abstract

A novel and efficient method has been developed for the direct synthesis of substituted imidazoles through the reaction of styrenes and benzylamines with the assistance of I₂-DMSO concerted system. The reactions proceed efficiently under open air and solvent-free conditions to afford a wide variety of substituted imidazoles in good yields. A productive large-scale synthesis also has been performed to target highly substituted heterocyclic motifs. The present protocol offers metal- and solvent-free process, mild conditions, easily accessible reactants, and operational simplicity to achieve an assembly of substituted N-heterocyclic compounds.

Key words

metal- and solvent-free - iodine - DMSO additive - substituted imidazoles - 1,2,3-triazole derivatives

Publication History

Received: 06 September 2022

Accepted after revision: 12 October 2022

Accepted Manuscript online:
12 October 2022

Article published online:
16 November 2022

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