One-Pot Iron-Catalyzed Cross-Coupling Reactions of Aryl Chlorides and Aryl Bromides

Yi-Bing Yin; Xiao-Shui Peng; Henry N. C. Wong

doi:10.1055/a-2042-3533

Synthesis, Table of Contents

Synthesis 2023; 55(14): 2253-2260
DOI: 10.1055/a-2042-3533

paper

Special Issue Honoring Prof. Guoqiang Lin’s Contributions to Organic Chemistry

One-Pot Iron-Catalyzed Cross-Coupling Reactions of Aryl Chlorides and Aryl Bromides

Yi-Bing Yin

^aDepartment of Chemistry, and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, P. R. of China

,

Xiao-Shui Peng ∗

^aDepartment of Chemistry, and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, P. R. of China

^bSchool of Science and Engineering, Shenzhen Key Laboratory of Innovative Drug Synthesis, The Chinese University of Hong Kong (Shenzhen), Longgang District, Shenzhen, P. R. of China

,

Henry N. C. Wong∗

^aDepartment of Chemistry, and State Key Laboratory of Synthetic Chemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, P. R. of China

^bSchool of Science and Engineering, Shenzhen Key Laboratory of Innovative Drug Synthesis, The Chinese University of Hong Kong (Shenzhen), Longgang District, Shenzhen, P. R. of China

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Abstract

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Abstract

A one-pot iron-catalyzed cross-coupling protocol involving aryl chlorides, aryl bromides and magnesium metal was developed towards the construction of unsymmetrical biaryls. The key procedure of this reaction is the in situ generation of Grignard reagents.

Key words

iron-catalyzed - cross-coupling - one-pot reaction - aryl chlorides - aryl bromides

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References

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