A New One-Pot Synthesis of 3,6-Disubstituted Pyridazines Starting from β-Nitro-β,γ-Unsaturated Ketones

Muhammad E. I. Khan; Lixia Yuan; Marino Petrini; Alessandro Palmieri

doi:10.1055/a-2114-7673

Synthesis, Table of Contents

Synthesis 2023; 55(19): 3204-3208
DOI: 10.1055/a-2114-7673

paper

A New One-Pot Synthesis of 3,6-Disubstituted Pyridazines Starting from β-Nitro-β,γ-Unsaturated Ketones

Authors

Muhammad E. I. Khan

^aGreen Chemistry Group, School of Sciences and Technology, Chemistry Division, University of Camerino ChIP Research Center, Via Madonna delle Carceri, 62032 Camerino (MC), Italy
Lixia Yuan

^aGreen Chemistry Group, School of Sciences and Technology, Chemistry Division, University of Camerino ChIP Research Center, Via Madonna delle Carceri, 62032 Camerino (MC), Italy

^bInstitute of BioPharmaceutical Research, Liaocheng University, Liaocheng 252059, People’s Republic of China
Marino Petrini

^aGreen Chemistry Group, School of Sciences and Technology, Chemistry Division, University of Camerino ChIP Research Center, Via Madonna delle Carceri, 62032 Camerino (MC), Italy
Alessandro Palmieri ∗

^aGreen Chemistry Group, School of Sciences and Technology, Chemistry Division, University of Camerino ChIP Research Center, Via Madonna delle Carceri, 62032 Camerino (MC), Italy

Abstract

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Abstract

A new one-pot preparation of 3,6-disubstituted pyridazines starting from β-nitro-β,γ-unsaturated ketones and hydrazine monohydrate is presented. The protocol entails two sequential steps, leading to the isolation of the title targets in satisfactory overall yields tolerating a good variety of additional functionalities.

Key words

pyridazines - heterocycles - cyclization - nitroolefins - one-pot

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References

References

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Supplementary Material

Supporting Information (PDF)