Transition-Metal-Free and Selective Deconstructive Carbonyl Olefination of α-Hydroxy Ketones: A Complementary Approach to Knoevenagel Reaction

Sandeep Sandeep; Vaneet Saini; Chayawan Chayawan; Ganga R. Chaudhary; Paloth Venugopalan; Anil Kumar

doi:10.1055/a-2114-7802

Synthesis, Table of Contents

Synthesis 2023; 55(19): 3186-3194
DOI: 10.1055/a-2114-7802

paper

Transition-Metal-Free and Selective Deconstructive Carbonyl Olefination of α-Hydroxy Ketones: A Complementary Approach to Knoevenagel Reaction

Authors

Sandeep Sandeep

^aDepartment of Applied Sciences, University Institute of Engineering and Technology, Panjab University, Chandigarh 160014, India

^bDepartment of Chemistry, Panjab University, Chandigarh 160014, India
Vaneet Saini

^bDepartment of Chemistry, Panjab University, Chandigarh 160014, India
Chayawan Chayawan

^cDepartment of Chemistry, National Institute of Technology, Hamirpur, Himachal Pradesh 177005, India
Ganga R. Chaudhary

^bDepartment of Chemistry, Panjab University, Chandigarh 160014, India
Paloth Venugopalan

^bDepartment of Chemistry, Panjab University, Chandigarh 160014, India
Anil Kumar ∗

^aDepartment of Applied Sciences, University Institute of Engineering and Technology, Panjab University, Chandigarh 160014, India

Abstract

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Abstract

While the carbonyl olefination has been extensively studied and well documented, use of α-hydroxy ketones as precursors for the carbonyl olefination is not reported, till date. Herein, a transition-metal-free and selective Knoevenagel-type deconstructive carbonyl olefination of α-hydroxy ketones using arylacetonitriles under mild reaction conditions is presented. The reaction affords valuable scaffolds of acrylonitriles with the use of α-hydroxy ketones as precursors for carbonyl olefination.

Key words

deconstructive - carbonyl olefination - α-hydroxy ketones - Knoevenagel reaction

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References

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Supplementary Material

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