An electrochemical approach for the Minisci-type acylation of quinoxalines with α-keto
acids as the acyl radical precursors is reported. With the assistance of TFA as the
key additive, acylated quinoxalines were constructed in synthetically useful yields.
The distinguishable features of this electrochemical protocol include catalyst- and
external oxidant-free conditions, and operational simplicity.
Key words
electrosynthesis - Minisci reaction - acyl radical - α-keto acids - anodic oxidation