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Synthesis 2024; 56(14): 2234-2238
DOI: 10.1055/a-2235-5080
DOI: 10.1055/a-2235-5080
paper
Short Synthesis of Dopamine Agonist Rotigotine
Autor*innen
The authors thank the Council of Scientific and Industrial Research (CSIR), C.S. thanks the University Grants Commission (UGC), and SK thanks CSIR for a research fellowship. S. C. thanks the Science and Engineering Research Board (SERB), Government of India for J C Bose fellowship (SB/S2/JCB-002/2015).
Abstract
A practical and short synthesis of FDA approved drug, Rotigotine, is achieved in two steps from 5-methoxy-2-tetralone, which in turn was synthesised by [4+2] cycloaddition of the in situ generated methoxyaryne from its precursor aryl triflate with benzyloxybutadiene or from 4-methoxyindanone via ring expansion using trimethylsilyldiazomethane.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2235-5080.
- Supporting Information (PDF) (opens in new window)
Publikationsverlauf
Eingereicht: 10. November 2023
Angenommen nach Revision: 27. Dezember 2023
Accepted Manuscript online:
27. Dezember 2023
Artikel online veröffentlicht:
29. Januar 2024
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