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Am J Perinatol 2024; 41(14): 1887-1894
DOI: 10.1055/a-2259-0101
Review Article

Gut Microbiota and Neonatal Acute Kidney Injury

Kun Yang
1   Division of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China
2   Department of Perinatology, The Affiliated Hospital of Southwest Medical University, Luzhou, China
3   Sichuan Clinical Research Center for Birth Defects, Luzhou, China
,
Hongxia He
1   Division of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China
2   Department of Perinatology, The Affiliated Hospital of Southwest Medical University, Luzhou, China
3   Sichuan Clinical Research Center for Birth Defects, Luzhou, China
,
Wenbin Dong
1   Division of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China
2   Department of Perinatology, The Affiliated Hospital of Southwest Medical University, Luzhou, China
3   Sichuan Clinical Research Center for Birth Defects, Luzhou, China
› Author Affiliations
Funding This article was supported by the National Natural Science Foundation of China (grant no.: 81571480), Sichuan Science and Technology Department Major Science and Technology Special Project (grant no.: 22ZDYF1470), and Luzhou Municipal People's Government-Southwest Medical University Science and Technology Strategic Cooperation Project (grant no.: 2020LZXNYDJ03).
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Abstract

Objective To characterize the relationship between gut microbiota and neonatal acute kidney injury biomarkers based on the gut-kidney axis.

Study Design The Pubmed database was primarily searched to include relevant literature on gut microbiota and neonatal acute kidney injury biomarkers, which was subsequently organized and analyzed and a manuscript was written.

Results Gut microbiota was associated with neonatal acute kidney injury biomarkers. These biomarkers included TIMP-2, IGFBP-7, VEGF, calbindin, GST, B2MG, ghrelin, and clusterin.

Conclusion The gut microbiota is strongly associated with neonatal acute kidney injury biomarkers, and controlling the gut microbiota may be a potential target for ameliorating neonatal acute kidney injury.

Key Points

  • There is a bidirectional association between gut microbiota and AKI.

  • Gut microbiota is closely associated with biomarkers of nAKI.

  • Manipulation of gut microbiota may improve nAKI.

Keywords

gut microbiota - neonatal acute kidney injury - gut–kidney axis - biomarkers

Authors' Contributions

K.Y. and W.D. designed the manuscript. K.Y. and H.H. collected data for the manuscript. K.Y. wrote the manuscript. K.Y., H.H., and W.D. revised the manuscript. All authors contributed to the manuscript and approved the submitted version.




Publication History

Received: 31 July 2023

Accepted: 30 January 2024

Accepted Manuscript online:
01 February 2024

Article published online:
26 February 2024

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