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Synthesis 2025; 57(02): 380-388
DOI: 10.1055/a-2380-3855
DOI: 10.1055/a-2380-3855
paper
Special Topic Dedicated to Prof. H. Ila
Direct Multicomponent Synthesis of C3-Arylated Pyrroles under Catalyst-Free Conditions
Authors
The authors acknowledge the financial support by DST-SERB, New Delhi (CRG/2020/003424) for this work.
Abstract
An operationally simple catalyst-free protocol for the direct regiospecific synthesis of C3-arylated/alkenylated pyrroles has been developed. The enamine-intermediate, in situ generated from succinaldehyde and a primary amine, was trapped with activated carbonyls before the Paal–Knorr reaction in a direct multicomponent ‘just-mix’ protocol to furnish pyrroles in good yields. Several C3-substituted N-alkylpyrroles have been prepared under open-flask conditions, avoiding protection-deprotection chemistry.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/a-2380-3855.
- Supporting Information (PDF)
Publication History
Received: 05 June 2024
Accepted after revision: 05 August 2024
Accepted Manuscript online:
05 August 2024
Article published online:
04 September 2024
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