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Eur J Pediatr Surg 2025; 35(03): 208-218
DOI: 10.1055/a-2471-6435
Original Article

Global Prevalence of Duodenal Atresia in Trisomy 21: A Systematic Review and Meta-Analysis

Dana Khaldun Atiyat 
1   School of Medicine, The University of Jordan, Amman, Jordan
,
Dina A. Al-Nusair
1   School of Medicine, The University of Jordan, Amman, Jordan
,
Abdulrhman Alhajahjeh
1   School of Medicine, The University of Jordan, Amman, Jordan
,
Mohammad Yousef Al-Awadi
1   School of Medicine, The University of Jordan, Amman, Jordan
,
Emad Aborajooh
2   Department of Surgery and Anesthesia, School of Medicine, Mu'tah University, Mu'tah, Karak, Jordan
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Abstract

Introduction Duodenal atresia is one of significant causes of neonatal intestinal obstruction. It often co-occurs with Down syndrome. This study is conducted to estimate the global prevalence of duodenal atresia in Down syndrome patients and to investigate associated factors.

Methods Conducting a systematic review with meta-analysis of 18 eligible studies reporting duodenal atresia prevalence in pediatric Down syndrome patients. Study quality is assessed using the Newcastle-Ottawa Scale. The subgroup analysis on region, study quality, publication year, and design is addressed. Gender-specific prevalence rates are examined.

Results The pooled prevalence of duodenal atresia in Down syndrome is 3.0%, with significant heterogeneity. The Middle East reports a higher prevalence of 6.0%, while Latin America, India, and Canada exhibit a lower prevalence of 1.0%. High-quality studies demonstrate 2% prevalence, while moderate-quality studies report 4.0%. Gender analysis indicates a similar incidence for females and males at 3.0%. Prevalence varies with study design: case-control studies report 4.0%, cross-sectional studies report 2.0%, and prospective cohort studies report 2.0%.

Conclusions Duodenal atresia is common in Down syndrome patients, affecting 3.0% of the patients worldwide. Regional variations exist, necessitating further investigation. Gender does not significantly impact prevalence. This study highlights the need for region-specific research to enhance clinical decision-making for individuals with Down syndrome and duodenal atresia.

Keywords

Down syndrome - duodenal atresia - prevalence - trisomy 21

Supplementary Material



Publication History

Received: 14 July 2024

Accepted: 14 November 2024

Article published online:
11 December 2024

© 2024. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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