Bilateral Toxic Keratopathy Associated with Hydrogen Peroxide

Introduction

Hydrogen peroxide is a disinfectant commonly used in lens care solutions, eliminating microorganisms by producing free radicals that disrupt cell membranes and vital cellular components. It has been utilized for contact lens cleaning since the 1970 s [1]. Corneal toxicity can result from chemical injury as well as topic or systemic medications [2], [3]. The clinical signs of corneal toxicity vary widely and may include superficial punctate keratitis pseudodendritic keratitis, filamentary keratitis, persistent epithelial defects, or even severe ulcerative keratitis [2].

Publication History

Received: 27 October 2024

Accepted: 06 January 2025

Article published online:
27 February 2025

• References

• 1 Gabriel MM, McAnally C, Chen H. et al. Hydrogen Peroxide Disinfecting Solution for Gas Permeable Contact Lenses: A Review of the Antimicrobial Efficacy, Compatibility, and Safety Performance of a One-Step Lens Care System. Clin Optom (Auckl) 2021; 13: 7-14
• 2 Dart J. Corneal toxicity: the epithelium and stroma in iatrogenic and factitious disease. Eye (Lond) 2003; 17: 886-892
• 3 DeRosa AJ. Toxic keratopathy. Int Ophthalmol Clin 1998; 38: 15-22
• 4 Rigas B, Huang W, Honkanen R. NSAID-induced corneal melt: Clinical importance, pathogenesis, and risk mitigation. Surv Ophthalmol 2020; 65: 1-11