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Synfacts 2025; 21(05): 474
DOI: 10.1055/a-2558-0573
DOI: 10.1055/a-2558-0573
Metals in Synthesis
Visible-Light-Driven Gold-Catalyzed Cross-Coupling of Aryl Bromides with Carboxylic Acids
Wu J,
Guo F,
Yi C,
Yang R,
Lei X,
Xia Z *.
Beijing Institute of Technology, P. R. China
Photosensitized Gold-Catalyzed Cross-Couplings of Aryl Bromides.
J. Am. Chem. Soc. 2025;
147: 5839-5850
DOI: 10.1021/jacs.4c14501
Photosensitized Gold-Catalyzed Cross-Couplings of Aryl Bromides.
J. Am. Chem. Soc. 2025;
147: 5839-5850
DOI: 10.1021/jacs.4c14501
Keywords
aryl bromides - carboxylic acids - cross-coupling - energy transfer - gold catalysis - photocatalysis
Significance
Xia and co-workers report a photosensitized gold-catalyzed protocol for the cross-coupling of aryl bromides with carboxylic acids. The reaction takes place under mild conditions, which is of note considering the usual low reactivity of aryl bromides in gold catalysis.
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Comment
Experimental and computational studies revealed that the reaction proceeds via a photoinduced energy transfer (EnT) that enables the oxidative addition of the gold(I) complex to the aryl bromide. A second EnT event facilitates reductive elimination of the aryl–Au(III) complex, thereby closing the catalytic cycle.
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Publication History
Article published online:
22 April 2025
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