Biopsy-proven Orbital Sarcoidosis after SARS-CoV-2 mRNA Vaccination

Introduction

Pfizer-BioNTech mRNA vaccine (BNT162b2) was used for immunization against Coronavirus disease 2019 (COVID-19). Many side effects involving different medical systems have been reported following widespread vaccination programs. The list of associated ocular inflammatory adverse events after administration of COVID-19 vaccines includes thyroid eye disease, orbital inflammatory pseudotumor, Tolosa-Hunt syndrome, superior ophthalmic vein thrombosis, choroiditis, nerve palsies, optic neuritis, corneal graft rejection, and uveitis [1], [2], [3], [4], [5], [6], [7], [8], [9], [10], [11]. To the best of the authorʼs knowledge, no study has been found the orbital sarcoidosis following COVID-19 vaccination. We report a case of proven systemic sarcoidosis which also involved the orbit initially presenting as periorbital swelling after the second dose of the Pfizer-BioNTech mRNA vaccine. We believe this to be the first such report. This study adhered to the tenets of the Declaration of Helsinki.

Publikationsverlauf

Eingereicht: 26. November 2024

Angenommen: 18. April 2025

Artikel online veröffentlicht:
08. August 2025

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