Electrocatalytic Deoxyfluorination of Benzyl Alcohols with SF6 as a Fluorinating Agent

Shan Zhu; Yue Zhao; Fengxiang Ma; Yumei Song; Wei Liu; Jun Cao; Abudu Rexit Abulikemu; Xisheng Wang

doi:10.1055/a-2637-3568

Synthesis, Table of Contents

Synthesis 2025; 57(19): 2825-2830
DOI: 10.1055/a-2637-3568

Paper

Electrocatalytic Deoxyfluorination of Benzyl Alcohols with SF₆ as a Fluorinating Agent

Authors

Shan Zhu

¹Electric Power Research Institute, State Grid Anhui Electric Power Co Ltd, Hefei, China
Yue Zhao

¹Electric Power Research Institute, State Grid Anhui Electric Power Co Ltd, Hefei, China
Fengxiang Ma

¹Electric Power Research Institute, State Grid Anhui Electric Power Co Ltd, Hefei, China
Yumei Song

¹Electric Power Research Institute, State Grid Anhui Electric Power Co Ltd, Hefei, China
Wei Liu

¹Electric Power Research Institute, State Grid Anhui Electric Power Co Ltd, Hefei, China
Jun Cao

¹Electric Power Research Institute, State Grid Anhui Electric Power Co Ltd, Hefei, China
Abudu Rexit Abulikemu

²Institution of Advanced Technology, University of Science and Technology of China, Hefei, China
Xisheng Wang

²Institution of Advanced Technology, University of Science and Technology of China, Hefei, China

Abstract

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Abstract

Emerging as the basic structural units in a variety of bioactive molecules, developing straightforward and efficient methods for synthesizing benzylic fluorinated compounds is of considerable significance. Herein, an electrocatalytic strategy utilizing sulfur hexafluoride (SF₆) as a fluorinating reagent to transform benzylic alcohols into benzyl fluorides has been developed under mild conditions. This reaction is compatible with several substrate backbones and avoids the excessive usage of chemical reductants, which provides new routes for the efficient utilization and degradation of SF₆, the potent greenhouse gas.

Keywords

Electrocatalysis - Deoxyfluorination - Sulfur hexafluoride - Benzyl alcohol - C–F bond

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References

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Supplementary Material

Supplementary Material (PDF)