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Synthesis 2025; 57(19): 2825-2830
DOI: 10.1055/a-2637-3568
DOI: 10.1055/a-2637-3568
Paper
Electrocatalytic Deoxyfluorination of Benzyl Alcohols with SF6 as a Fluorinating Agent
Authors
Supported by: Anhui Electric Power Research Institute of State Grid B3120523000Z
Abstract
Emerging as the basic structural units in a variety of bioactive molecules, developing straightforward and efficient methods for synthesizing benzylic fluorinated compounds is of considerable significance. Herein, an electrocatalytic strategy utilizing sulfur hexafluoride (SF6) as a fluorinating reagent to transform benzylic alcohols into benzyl fluorides has been developed under mild conditions. This reaction is compatible with several substrate backbones and avoids the excessive usage of chemical reductants, which provides new routes for the efficient utilization and degradation of SF6, the potent greenhouse gas.
Publication History
Received: 15 April 2025
Accepted after revision: 16 June 2025
Accepted Manuscript online:
16 June 2025
Article published online:
24 July 2025
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Selected examples for the synthesis of benzyl fluorides: