Synthesis of Cyclopropane α-Amino Acids

Keywords

rhodium catalysis - nitrocyclopropane carboxylate - cyclopropane α-amino acids - zinc-mediated reduction

Significance

Cyclopropane α-amino acids are significant due to their unique structural properties and diverse applications in synthetic chemistry and biological systems. In this study, the authors synthesized cyclopropane α-amino esters by zinc-mediated reduction of nitrocyclopropane carboxylates.

 

MissingLinkText

Comment

The key precursor nitrocyclopropane carboxylates can be readily prepared through treatment of α-nitroesters and iodobenzene diacetate or α-nitro-α-diazoesters with a Rh(II) catalyst and an olefin. This protocol is practically simple and is useful for the synthesis of cyclopropane α-amino esters.

 

MissingLinkText

 

MissingLinkText

Publikationsverlauf

Artikel online veröffentlicht:
23. Juli 2025