DOI: 10.1055/s-00000131

Synfacts

Issue 08 · Volume 21 · August 2025 DOI: 10.1055/s-015-62003

Synthesis of Natural Products

  • z759

    All PDFs of this category

  • 759

    Total Synthesis of (±)-Ambiguine P

  • 760

    Total Synthesis of (–)-Illisimonin A

  • 761

    Total Synthesis of (+)-Rubriflordilactone A

  • 762

    Total Synthesis of (–)-Isodaphlongamine H

  • 763

    Total Synthesis of (–)-Vallesamidine

  • 764

    Total Synthesis of (–)-Psiguadial A

  • 765

    Total Synthesis of (±)-Epoxysorbicillinol

    • Synthesis of Heterocycles

  • z767

    All PDFs of this category

  • 767

    Enantioselective Synthesis of Spirocyclic Pyrrolidine Derivatives

  • 768

    Selective C–H Allylation of Tertiary Anilines

  • 769

    In Situ Generation of a Hypervalent Iodine Catalyst for the Fluorination of Ketones

  • 770

    A Facile Method for Preparing 5-Amino-1H-Pyrazole-4-Carbonitriles

  • 771

    Enantioselective Intermolecular Hydroarylation of (Hetero)aryl Halides

  • 772

    Accessing Macrocycles via a Strain-Release and Palladium-Mediated Templating Strategy

  • 773

    Regioselective meta-Nitration of Azines

  • 774

    Scalable Nickel-Mediated Formation of (Hetero)aryl Nitriles

  • 775

    Enantioselective Synthesis of 2-Aza-bicyclo[2.1.1]hexanes

    • Synthesis of Materials and Unnatural Products

  • z777

    All PDFs of this category

  • 777

    Thermally Degradable Photopolymers for 3D Printing

  • 778

    A Low-Cost, Optical-Glass Photopolymer Containing a Disulfide Bond

  • 779

    Spin-Tuned Divergent Topochemical Polymerizations

  • 780

    A Chiral Double [8]Helicene

  • 781

    An Azulene-Composed Non-Alternant Isomer of Perylene

  • 782

    A [6+6] Cycloaddition Enabled by Anthrylethynylaniline

  • 783

    Aromatization-Driven Production of Aminoxoboranes

  • 784

    Rhodium-Catalyzed Mechanochemical Hydrogenation of Polycyclic Aromatic Hydrocarbons

  • 785

    N-Heterobicyclic Olefins: A New Type of Synthon and Ligand

  • 786

    Photo-degradation of Polyoxymethylenes into Imidazolidines

    • Metals in Synthesis

  • z787

    All PDFs of this category

  • 787

    Cobalt-Catalyzed Enantioselective Hydrogenation of 2-Hydroxy Ketones to Access 1,2-Diols

  • 788

    A Light Way to Oxidize Benzylic C(sp3)–H Bonds Using Copper

  • 789

    A Decarboxylative Acylation Strategy for the Enantioconvergent Synthesis of α-Oxygenated Ketones

  • 790

    Radical Sorting Enables Decarboxylative Monofluoromethylation under Nickel Catalysis

  • 791

    Synthesis of Polysubstituted Cyclobutenes by Nickel-Catalyzed Cross-Electrophile Coupling

  • 792

    Double C–H Functionalization Enables Access to ortho-Arylated Benzoic Acids

  • 793

    Copper-Catalyzed Asymmetric Allylic and Propargylic C–H Amidation under Light Irradiation

  • 794

    Mn-Catalyzed XAT of Diborylatediodomethane with Unactivated Olefins and Synthesis of Cyclopropanes

  • 795

    Dual Nickel/Photoredox-Catalyzed Decarboxylative Cross-Coupling of Carboxylic Acids with Aldehydes

  • 796

    Synthesis of Complex Tetrahydrofurans via a Charge-Relocation Strategy

  • 797

    Cobalt-Catalyzed Enantioconvergent Negishi Cross-Coupling of α-Bromo-α-Fluoro Ketones

  • 798

    Photoredox-Catalyzed Aminochlorination of Unactivated Alkenes

  • 799

    Palladium-Catalyzed Asymmetric Cross-Coupling of Cyclobutanecarbaldehyde-Derived N-Tosylhydrazones

  • 800

    Nickel-Catalyzed Desulfonylative Suzuki−Miyaura Cross-Coupling of Unactivated Aryl Sulfones

  • 801

    Nickel-Catalyzed Asymmetric Synthesis of α-Arylated Ketones from two Distinct Alkenes

  • 802

    Copper-Catalyzed Asymmetric Borylalkylation of Styrenes

  • 803

    Titanium-Catalyzed Reductive Ugi Reaction with Carboxylic Acids

  • 804

    Palladium-Catalyzed Synthesis of Benzo-Fused Cycloheptanones

  • 805

    Cerium-Catalyzed Enantioselective 6π Electrocyclization of Triaryldivinyl Ketones

  • 806

    Epoxide Radical Anions in Asymmetric Copper Catalysis

  • 807

    Enantioselective C(sp2)–H Cyanation of Allenes under Copper Catalysis

  • 808

    Nickel-Catalyzed Reductive Coupling of 2-Pyridyl Esters with Alkyl Chlorides

  • 809

    Hydroalkoxylation of Styrenes with Acetal-Based Peroxides under Copper Hydride Catalysis

  • 810

    Dynamic Kinetic Resolution of Axially Chiral Compounds – Catalyst Selective for Both Point and Axial Chirality

  • 811

    Access to Axially Chiral Alkylidene Azacycloalkanes by Rhodium(I)-Catalyzed Carbene Coupling

  • 812

    Photochemical Reductive Palladium Homocoupling of Diene Tethered Aryl Iodides

    • Polymer-Supported Synthesis

  • z813

    All PDFs of this category

  • 813

    Oxidative Nitrogenation of Alkenes through C=C Bond Cleavage Using a Zeolite-Supported Copper Catalyst

  • 814

    Chemo- and Regioselective Deuteration of (Hetero)arenes Using SiO2-Supported Iridium Nanoparticles

  • 815

    Photoinduced Multicomponent Reactions Forming Imidazolidines Using Sulfonic Acid Modified g-C3N4

  • 816

    Si–F Activation for Si–O Bond-Forming Reactions Using a Cross-Linked Polymer-Supported Ruthenium Catalyst

  • 817

    4-Quinazolinones from Allylic Alcohols and o-Aminobenzamides Using a COF-Supported Ru Complex

  • 818

    An Amphiphilic Polymer-Supported Palladium Complex for the Suzuki–Miyaura Coupling in Water

  • 819

    Selective Synthesis of α,β-Unsaturated Aldehydes Using H2O2 Generated by an Electrochemical Reaction

  • 820

    Acceptorless Dehydrogenation of Alcohols Using Single-Atom Pt and Ir on NiO Nanosheet

  • 821

    Photocatalytic Aerobic Oxidation of Alkylbenzenes, Silanes, Thioethers, and CDC Reaction Using 3D-COF

  • 822

    A Coordination Polymer of a Pd6 Cluster: A Water-Compatible Hydrogenation Catalyst

  • 823

    Iodination of Electron-Deficient Arenes under Electrochemical Conditions

    • Organo- and Biocatalysis

  • z825

    All PDFs of this category

  • 825

    Light-Driven Enantioselective Acylation of Benzylic C–H Bonds Using Thiamine-Dependent Enzymes

  • 826

    Embedding a Triplet Sensitizer Into the Catalytic Pocket of an Enzyme to Enable Photocatalytic C–H Insertion

  • 827

    Organocatalytic Cyclopropanation of Olefins

  • 828

    Biocatalytic Enantiodivergent Synthesis of Cyclohexylidene-Based Axially Chiral Amines

  • 829

    Stereoretentive SN1 Reactions of Homoallylic Tertiary Alcohols via Cyclopropyl Carbinyl Carbocations

  • 830

    Dipolar Cycloaddition of Photoexcited Nitroarenes

  • 831

    Organocatalytic Asymmetric Synthesis of Azabicyclo[2.1.1]hexanes

  • 832

    1,2-Acyl Group Migration in Dihydrobenzofurans Enabled by Photochemical Skeletal Editing

  • 833

    Enantioselective Construction of Polycycles via Type II Intramolecular [5+2] Cycloadditions

    • Innovative Drug Discovery and Development

  • z835

    All PDFs of this category

  • 835

    Discovery and Development of INCB126503: A Potent and Selective FGFR2/3 Inhibitor

  • 836

    A Concise Formal Synthesis of (−)-Paroxetine

  • 837

    Leveraging Small-Molecule Heat Generation as a Noninvasive Apoptotic Tool

  • 838

    Reagent-Controlled Divergent Carbon Deletion of Quinolines via Carbon-Atom Scavengers

  • 839

    Development of Dual DAT/σR Inhibitor CM699 as a Potential Therapeutic for Stimulant Use Disorder

  • 840

    Tuning Chiral Catalysts with Achiral Additives

  • 841

    18F-Labeling of α,α-Difluoromethylalkanes in High Molar Activity

  • 842

    A 5-exo-trig Cyclization Strategy Crafts Modular Cyanine Probes for High-Contrast Biomarker Detection

  • 843

    Gram-Scale Synthesis of an Antibody Fucosylation Inhibitor

  • 844

    A Structurally Simplified Derivative Retains the Bioactivity of Colchicine

  • 845

    Hydrogen Sulfide Meets Phototherapy: A Synergistic Approach to Chronic Wound Treatment

  • 846

    Ketone Homologation with Titanium and DMF

  • 847

    A Novel and Safer Approach to Furazan Carboxylic Esters from Enamines

    • Peptide Chemistry

  • z849

    All PDFs of this category

  • 849

    Iron-Catalyzed Glycal 1,2-cis-Aminoglycosylation for the Synthesis of Biologically Active Tn Antigens

  • 850

    Thiol-Michael Addition of Thiolated Lipids at Dehydroalanine-Residue-Containing Peptides

  • 851

    Palladium-Catalyzed Coupling to Form α,α-Disubstituted Amino Acids

  • 852

    Racemization-Free Peptide Coupling Using a Green Coupling Agent

  • 853

    Enantioselective Synthesis of Unnatural Polar Amino Acids

  • 854

    Total Synthesis of the Cyclic Heptapeptide Stylissamide B

  • 855

    Synthesis of Quaternary Glutamates via Direct Enantioselective Allylic Alkylation of α‐Amino Esters

  • 856

    Synthesis of Amino Amides via Asymmetric Vicinal and Remote Hydroamination of Olefins

  • 857

    Photocatalyzed Desulfurization Editing of Methionine in Peptides

  • 858

    Incorporation of Thioate Groups into Peptides Using a CS2-Mediated Solid-Phase Strategy

  • 859

    Late-Stage Functionalization of Peptides with Amines Using a Solid-Phase Approach

  • 860

    Synthesis of Cyclopropane α-Amino Acids

    • Flow Chemistry

  • z861

    All PDFs of this category

  • 861

    Expedient Access to Functionalized Cyclopropenes via Continuous Flow Conditions

  • 862

    An Atom-Economic Approach to Cyclic Sulfonamides via Photochemical [2+2] Cycloaddition

  • 863

    Continuous-Flow Preparation of Nitrofuran Active Pharmaceutical Ingredients

    • Correction

  • 865

    Correction: A Practical Strategy for the Chemoselective Synthesis of O-Alkylated Serine and Threonine Derivatives

  • 866

    Correction: Rationally Designed Phosphine Ligand to Enable Challenging Palladium-Mediated Aminations