Chiral Ligands with 1,10-Phenanthroline Scaffolds for Copper-Catalyzed Enantioselective C(sp3)−H Bond Amidation

Abstract

We herein report newly developed C₂-symmetric 2,9-diarylphenanthroline ligands with easily modified chiral amide motifs, which enable Cu-catalyzed intramolecular C(sp³)–H amidation of mesylcarbamates to deliver 2-oxazolidone derivatives with up to 88:12 er.

Keywords

Chiral 1,10-phenanthroline - Copper catalysis - Nitrene C–H insertion - Carbamate ester - β-Amino alcohols

Publication History

Received: 20 May 2025

Accepted after revision: 01 July 2025

Accepted Manuscript online:
01 July 2025

Article published online:
22 July 2025

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