Nickel-Catalyzed Reductive Cross-Coupling of Imines with α-Imino Esters for the Construction of α,β-Diamino Acid Derivatives

Abstract

A nickel-catalyzed reductive cross-coupling reaction of different imines has been developed. This method enables the first reductive cross-coupling between aryl/alkyl imines and α-imino esters, affording α,β-diamino acid derivatives bearing quaternary carbon centers in a single-step process. This imine umpolung strategy exhibits several advantages, such as mild conditions and broad functional group compatibility.

Keywords

Nickel catalysis - Imines - α-Imino esters - Reductive cross-coupling - α,β-Diamino acid derivatives

Publication History

Received: 29 May 2025

Accepted after revision: 04 July 2025

Article published online:
08 August 2025

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