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DOI: 10.1055/a-2653-4465
Near-Infrared-Activated Pd@Au Nanorods for Prodrug and Prodye Uncaging
Near-Infrared Light-Accelerated Bioorthogonal Drug Uncaging and Photothermal Ablation by Anisotropic Pd@Au Plasmonic Nanorods.
J. Am. Chem. Soc. 2025;
147: 23980-23990
DOI: 10.1021/jacs.5c07261
Significance
The authors develop anisotropic palladium-gold (Pd@Au) nanorods that catalyze the uncaging of prodrugs and prodyes under near-infrared (NIR) light. In addition, this study introduces a new masking group, POxOC, allowing effective drug activation in both the presence and absence of NIR stimulation. In vitro and in vivo experiments in zebrafish xenograft models demonstrate efficient drug release, tumor suppression, and minimal toxicity, establishing Pd@Au nanorods as a versatile platform for targeted, light-controlled chemotherapy.
Comment
POxOC, a derivative of POBOC, offers a significant improvement in uncaging performance
for chemotherapeutics. Unlike bulky or hydrophobic groups that may hinder drug delivery
or require harsh conditions for release, POxOC enables efficient Pd-catalyzed uncaging
under biocompatible conditions. Additionally, the discovered thermally induced cleavage
by POxOC makes it versatile and effective for in vivo applications.
Publication History
Article published online:
27 August 2025
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