DOI: 10.1055/s-00000131

Synfacts

Issue 09 · Volume 21 · September 2025 DOI: 10.1055/s-015-62114

Synthesis of Natural Products

z867
All PDFs of this category
867
Total Synthesis of (±)-Lycojapomines A and B
868
Total Synthesis of (+)-Swinhoeisterol A
869
Total Synthesis of (±)-Penisuloxazin A
870
Total Synthesis of (+)-Rhodocorane L
871
Total Synthesis of (±)-Streptoglyceride A
872
Total Synthesis of (±)-Tubingensin A
873
Total Synthesis of (+)-Cyanthiwigin U

Synthesis of Heterocycles

z875
All PDFs of this category
875
Synthesis and Properties of Bicyclic Fluorinated Piperidine Derivatives
876
Synthesis of 6-Azabicyclo[3.1.1]heptanes Through Light-Mediated Intramolecular [2+2] Cycloaddition
877
Diastereoselective Synthesis of Functionalized (Hetero)cyclohexane-4-carboxylate Derivatives
878
Facile Access to 7-Azaindolines and the Corresponding Azaindoles
879
Conversion of Iodo-Bicyclopentanes Into Aminomethyl Bicyclobutanes
880
Diastereoselective Synthesis of Tetrahydrofuran/Tetrahydropyran Derivatives
881
Synthesis of 3-Azetidinones through Light-Driven C–C Bond Formation
882
Facile Introduction of the SF5-Moiety Into Azetidines and Cyclobutanes Using a Shelf-Stable Reagent
883
Synthesis of Functionalized Bicyclic Heterocycles as Bioisosteres for meta-Substituted (Hetero)arenes
884
Facile Access to Spiroketals through Electrochemistry
885
Iron-Catalyzed Cross-Electrophile Coupling
886
C(sp2)–C(sp3) Bond Formation for Pyridines
887
meta-Selective Fluorination of Pyridine Derivatives
888
Diastereoselective α-(Hetero)Arylation of 4-Silyloxy Piperidines
889
α-Functionalization of Pyrrolidines to Access Spirocyclic Proline Derivatives

Synthesis of Materials and Unnatural Products

z891
All PDFs of this category
891
Light-Triggered, High-Resolution Doping of Organic Semiconductors
892
Azulene-Embedded PAHs from [2+2+1] Annulation–Oxidation
893
Preparation and Reactivity of a Stable Hexaphenyl Diphosphonium Dication
894
1,4-Diboraanthracenes via 1,2-Naphthodiboretes
895
Boron–Carbon Diradical-Mediated Boracycles
896
Pyrazole-Enabled Controlled SNAr Polymerization of Arynes
897
Carbon Dioxide Mediated Controlled Anionic Polymerization
898
Cyclic Olefin Polymers from Group-Transfer Radical Cyclopolymerization
899
Bifunctional Catalysts for Ring-Opening Alternating Copolymerization
900
Single Catalyst for Olefin Block Copolymers

Metals in Synthesis

z901
All PDFs of this category
901
Photochemical Copper-Catalyzed Chloroacylation of Unsaturated C–C Bonds
902
Copper-Mediated Deacetylative Fluorination of Methyl Ketones to Alkyl Fluorides
903
Synthesis of Diborylamines via the Iron-Catalyzed Hydroboration of Nitriles
904
Carbonylation of Gaseous Alkanes into Thioesters under Photoinduced Copper Catalysis
905
Dual-Metal-Catalyzed Shuttling of Isomeric Mixtures to Stereodefined Functionalized Products
906
Synthesis of Tertiary Nitro Compounds by Cobalt-Catalyzed Hydronitration of Alkenes
907
Synthesis of Protected Unnatural Amino Acids Enabled by an Ylide-Functionalized Phosphine
908
Palladium-Catalyzed Aminocarbonylation of Iodoarenes with Carbon Monoxide and Nitroarenes
909
Synthesis of Diastereomerically Enriched (Thio)phosphonates from Phosphinic Dichlorides
910
Synthesis of Triarylmethanes from Acylsilanes and Electron-Rich Arenes by Photoinduced Copper Catalysis
911
Easy Access to E- and Z-Alkenes through Cobalt-Catalyzed Semihydrogenation of Alkynes
912
Dealkylation of Aryl Alkyl Ethers under Photoinduced Copper Catalysis
913
Stereoselective Synthesis of 1,3-Diols from Vinyl-Substituted Cyclic Carbonates under Nickel Catalysis
914
Iridium-Photocatalyzed Difunctionalization of Alkenes Using N-Benzoyloxyamides
915
An Umpolung Approach towards the α-Allylation of α-Iminoesters under Cobalt Catalysis
916
A Novel Agent for the Metal-Catalyzed Methylthiolation of Aryl Electrophiles
917
Access to α-Amino Amides through Asymmetric Copper Amino Propargylation
918
Synthesis of 1,2-Dicarboxylic Acids from Unactivated Alkynes with CO2 under Iridium Photocatalysis
919
Enantioselective Synthesis of Indoyl Chromans Using a Gold–Catalyzed Arylative Cyclization
920
Palladium-Catalyzed β‑Selective C(sp3)–H Fluorination of Amides
921
Regulating Back-Electron Transfer in Nickel-Catalyzed Cross-Electrophile Couplings
922
Asymmetric Decarboxylative N-Alkylation of Amines Enabled by Dual Cobalt and Acridine Photocatalysis
923
Enantioselective Synthesis of Bis-Heterocycles via Palladium Domino Catalysis
924
Asymmetric Synthesis of [5,5]-Fused Bicycles by Nickel-Catalyzed 1,3-Cyclotelomerization of Butadiene
925
Highly Selective Azetidine Synthesis by Boryl Allylation of Azetines
926
Rhodium-Catalyzed C–C Bond Activation

Polymer-Supported Synthesis

z927
All PDFs of this category
927
Electrocatalytic Hydrogenation of Olefins
928
Palladium-Catalyzed Regio- and Enantioselective C–H Alkenylation under Electrocatalytic Redox Conditions
929
A Carbon-Supported Ag5Cu4 Nanocluster Catalyst for the Knoevenagel Condensation
930
Enantioselective Minisci-Type Addition to Heteroarenes Using Mesoporous g-C3N4 under Red-Light Irradiation
931
Deuteration of Hydrosilanes Using Ruthenium Nanoparticles on γ-Al2O3
932
A Nickel-Incorporated Pyridyl-Quinoline-Based COF for Cross-Couplings of Aryl Halides and Nucleophiles
933
A Metal-Free Ionic Porous Polymer Gel Catalyzed N-Formylation of Amines and Amides under CO2
934
A Polymer-Supported Palladium Catalyst for Tandem Borylation/Suzuki Coupling of Aryl Iodides
935
Formation of Phenylbenzimidoyl Cyanide Derivatives by Electrochemical Cyanation of Imines in Acetonitrile
936
A Polymeric Homochiral Manganese Catalyst for Asymmetric Benzylic Oxidation and Olefin Epoxidation

Organo- and Biocatalysis

z937
All PDFs of this category
937
Chiral Calcium Phosphate-Catalyzed Transfer Hydrogenation of β-Trifluoromethylated Nitroalkenes
938
Redox and Nucleophilic Catalysis of N-Heterocyclic Phosphinidene
939
Conquering Back Electron Transfer in Photochemistry
940
Chiral Ammonium Salt Catalyzed Synthesis of α-Tertiary Amines from Alkynyl Ketimines
941
Verdazyl Radicals as Organocatalysts for Redox-Neutral C–C Bond Formation
942
Stereoablative Enantioconvergent Hydrolysis of γ-Chiral Oximes
943
Harnessing Visible Light for Stereoselective Hydro- and Iodotrifluoromethylation of Alkynes
944
Dispersion-Driven Design of a General Asymmetric Transfer Hydrogenation Catalyst
945
Organophotocatalytic Transformation of Unactivated Olefins into α-CF3 Amines Catalyzed by Thiols

Innovative Drug Discovery and Development

z947
All PDFs of this category
947
Near-Infrared-Activated Pd@Au Nanorods for Prodrug and Prodye Uncaging
948
Reductive Sulfonamidation of Amides via Zirconium Hydride Catalysis
949
HAT/XAT-Enabled Selective Radical Monohalogenation
950
One-Pot Migrative Reductive Amination of Ketones
951
Ex-Chiral-Pool Synthesis of RIPK1 Inhibitor GDC-8264
952
Tunable, Platinum(IV)-Based Photocages via Click Ligation
953
Synthesis of Morphine Analogues with a Carbocyclic E-Ring
954
No Mixing Required: “Cocktail” Probe Unites Fluorophores for Unimolecular Multi-ROS Imaging
955
Improved Stereoselective Synthesis of Delgocitinib
956
Allylic Extension of Terminal Olefins
957
Radiolabeled Arylazopyrazole Ligand Reveals Light-Controlled Binding Kinetics at a GPCR

Peptide Chemistry

z959
All PDFs of this category
959
Introduction of Carbazolyl Phthalonitrile into Peptide Chains
960
Nickel(II)-Catalyzed Stereodivergent Reactions of N-Azidoacetyl Thioimides with Aromatic Acetals
961
Glycine Derivative Functionalization with Alkyl-trifluoromethyl Groups
962
Light-Driven Decarboxylative Oxygenation of Amino Acids and Peptides Using Diphenyl Diselenide
963
Synthesis of Pyrazinylglycine Derivatives through Dechlorinative Pyrazinylation
964
Trimethylsilyl Bromide Promoted Ligation of Tryptophan and Cysteine
965
Desulfurative Functionalization of Cysteine
966
N-Arylation of Peptides and Their Ligation in Organic Solvent
967
Synthesis of Thioarylated Cysteine and Cysteine-Containing Peptides
968
Copper-Catalyzed Late-Stage Functionalization for the Synthesis of Phenothiazine-Based Cyclopeptides
969
Zinc Chloride Mediated Claisen Rearrangement for the Synthesis of Allenic Amino Acids

Flow Chemistry

z971
All PDFs of this category
971
Electrochemical Generation of CO and Palladium-Catalyzed Carbonylation of Aryl Iodides in Flow
972
N-Benzylation of Amides under Batch and Continuous Flow Conditions Using a Zeolite-Supported Ru Catalyst
973
Photochemical Synthesis of Pyridino[2,1-b]quinazolinones Enhanced by Flow

Correction

975
Correction: Total Synthesis of (±)-Melohemsine K