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Synfacts 2025; 21(09): 901
DOI: 10.1055/a-2653-4501
Metals in Synthesis

Photochemical Copper-Catalyzed Chloroacylation of Unsaturated C–C Bonds

Contributor(s):
Mark Lautens 
,
Andrew G. Durant
Mandal T, Ghosh M, Paps H, Mandal T, Reißer O *. Universität Regensburg, Germany
A General Photocatalytic Platform for the Regio- and Stereoselective β-Chloroacylation of Alkenes and Alkynes Using a Heteroleptic Copper(I) Complex.

Nat. Catal. 2025;
8: 607-622
DOI: 10.1038/s41929-025-01357-y
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Keywords

copper - photocatalysis - acid chlorides - alkynes

Significance

Reiser and co-workers report on the chloroacylation of alkenes and alkynes using benzoyl chlorides. The reaction uses a photoactive heteroleptic CuI species to generate the acyl radical and control the C–Cl bond formation. Mechanistic studies highlight the role that the copper catalyst and the accompanying ligands have as the reaction progresses.


 

Comment

The products were shown to be synthetically versatile, allowing for the synthesis of dihydropyrazoles, allylic alcohols, aromatic compounds, and other functionalities. The authors were also able to functionalize the products for the formal syntheses of five drug compounds and three natural products.


 

 

Publication History

Article published online:
27 August 2025

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