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Synthesis 2025; 57(23): 3565-3578
DOI: 10.1055/a-2688-5484
Short Review
Published as part of the Special Topic C–S Bond Forming and Cleaving Reactions

Recent Advances in the Total Synthesis of Sulfur-containing Natural Products

Autoren

  • Sanghyeon Lee

    1   School of Advanced Fusion Studies, University of Seoul, Seoul, Republic of Korea (Ringgold ID: RIN35010)

  • Wonchul Lee 

    2   Department of Chemistry, Kangwon National University, Chuncheon, Republic of Korea (Ringgold ID: RIN34962)

This work was supported by the 2024 Research Fund of the University of Seoul for Sanghyeon Lee. Also this study was supported by 2022 Research Grant from Kangwon National University for Wonchul Lee.
Gefördert durch: Kangwon National University 2022 Research Grant
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Graphical Abstract

Abstract

Sulfur imparts distinctive reactivity, conformational bias, and redox versatility to natural products, giving rise to potent antibacterial, antiviral, anticancer, and enzyme-inhibitory activities. Over the past five years, highly regio- and stereoselective C–S bond-forming strategies have enabled concise access to increasingly complex sulfur frameworks. This review surveys representative total syntheses reported from March 2020 to January 2024, grouped by sulfur functionality—thioethers, disulfides, sulfoxides, thioacetals, thiazoles, thiazolines, and isothiazolinones—and shows how these advances shorten step counts, facilitate late-stage diversification, and provide a foundation for rapid structure–activity relationship studies of sulfur-rich scaffolds poised for therapeutic development.

Keywords

Total synthesis - Sulfur-containing natural products - Thioether - Disulfide - Oxysulfur - Thiazole - Thiazoline


Publikationsverlauf

Eingereicht: 10. Juli 2025

Angenommen nach Revision: 21. August 2025

Accepted Manuscript online:
21. August 2025

Artikel online veröffentlicht:
08. Oktober 2025

© 2025. Thieme. All rights reserved.

Georg Thieme Verlag KG
Oswald-Hesse-Straße 50, 70469 Stuttgart, Germany

 

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