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Synthesis 2025; 57(23): 3623-3628
DOI: 10.1055/a-2695-8185
DOI: 10.1055/a-2695-8185
Paper
Cu(acac)2-Catalyzed A3-(Aldehyde-amine-alkyne) Coupling Reaction for the Synthesis of a Wide Range of Propargylamines and Entry to Imidazo[1,2-a]pyridines
Autoren
Abstract
Cu(acac)2-catalyzed A3-coupling reactions involving an amine, an aldehyde, and a terminal alkyne were explored for the efficient synthesis of a broad range of propargylamines and imidazo[1,2-a]pyridines. This method demonstrates a wide substrate scope and delivers the desired products in good yields under mild reaction conditions. The protocol offers a straightforward and practical approach to accessing these valuable scaffolds, making it attractive for further synthetic applications.
Publikationsverlauf
Eingereicht: 23. Juni 2025
Angenommen nach Revision: 04. September 2025
Accepted Manuscript online:
04. September 2025
Artikel online veröffentlicht:
21. Oktober 2025
© 2025. Thieme. All rights reserved.
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