New Advances in Atroposelective Synthesis of Axial Chirality via Asymmetric Gold(I)-Catalyzed Annulation of Diazo-Alkynes

Abstract

Atropisomeric architectures, now as a characteristic of valuable chiral ligands and organocatalysts, are increasingly encountered in modern materials and pharmacy. More importantly, the Au-catalyzed diazo-alkyne carbocyclization has become a flexible tool for facile construction of carbocyclic compounds, yet the preparation of axial chirality via asymmetric gold-catalyzed intermolecular alkyne transformations is scarcely reported. This mini-review aims to summarize the latest development of the axial atroposelective synthesis via Au-catalyzed annulation of diazo-alkyne.

Keywords

Gold catalysis - Diazo-alkynes - Atroposelectivity - Annulation - Co-catalysis

Publication History

Received: 17 July 2025

Accepted after revision: 14 September 2025

Accepted Manuscript online:
14 September 2025

Article published online:
07 October 2025

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