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DOI: 10.1055/a-2751-3243
Der interessante Fall

Keratoconjunctivitis after Tralokinumab for Severe Atopic Dermatitis – A Case Report

Keratokonjunktivitis nach Tralokinumab bei schwerer atopischer Dermatitis – ein Fallbericht

Authors

  • Sadiq Said 

    1   Augenklinik Wettingen, Switzerland
    2   Department of Ophthalmology, University Hospital Zurich, University of Zurich, Switzerland

  • Felicia Hertkorn

    1   Augenklinik Wettingen, Switzerland

  • Pascal Knecht-Bösch

    1   Augenklinik Wettingen, Switzerland
    2   Department of Ophthalmology, University Hospital Zurich, University of Zurich, Switzerland

  • Martina Knecht-Bösch

    1   Augenklinik Wettingen, Switzerland
    2   Department of Ophthalmology, University Hospital Zurich, University of Zurich, Switzerland
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Background

Atopic dermatitis (AD), a form of eczema, constitutes the most common chronic inflammatory skin disease and affects around 220 million people worldwide [1], [2]. The condition typically manifests in early childhood, with reported prevalence rates of approximately 20% among children in Europe and the United States, while around 7% to 14% of adults remain affected [3], [4], [5], [6], [7]. The clinical presentation varies in severity and chronicity, primarily characterized by dry, itchy, and erythematous skin lesions, with lichenification in the chronic stages [2]. The pathophysiology of AD is incompletely understood, but current literature highlights genetic predisposition, skin barrier dysfunction, immune dysregulation, and environmental triggers [2], [8]. Beyond the physical burden, AD may significantly impair the quality of life, imposing psychological stress and social challenges on affected patients.

The treatment of AD highly depends on the severity of the disorder and ranges from elimination diets, moisturizers, topical corticosteroids and calcineurin inhibitors, to ultraviolet phototherapy and systemic immune-modulating agents [9], [10]. Over the last decade, the emergence of biologics as newer treatment options has shown promising results. Tralokinumab, an approved biologic that targets the interleukin 13 (IL-13) pathway, is used for patients aged 12 years and older with moderate to severe AD who are refractory or fail to adequately respond to conventional therapies [9]. Clinical trials have demonstrated significant improvements in patient-reported outcomes about skin lesions, itching, sleep disturbances, and quality of life, with a favorable overall safety profile [11]. However, reports on ocular side effects remain relatively limited.

Patients with AD may experience ocular involvement, with reported disease associations such as blepharitis, keratoconjunctivitis, keratoconus, and cataracts [12]. Such manifestations may further complicate the systemic management, as immunomodulatory therapies themselves can induce ocular side effects, most notably conjunctivitis [11]. Hence, this case report aims to raise awareness of ocular adverse events associated with tralokinumab treatment in AD.



Publication History

Received: 25 October 2025

Accepted: 12 November 2025

Article published online:
18 February 2026

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