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DOI: 10.1055/a-2759-6476
Radical Allylation of Vinyl Perfluorocyclic Sulfonamides Leading to 1,1,2,2,3,3-Hexafluorohex-5-ene-1-sulfonamides
Authors
This work was partially supported by Grants-in-Aid for Scientific Research (22K05116 and 25K00077) and JST-GteX (JPMJGX23SA and JPMJGX23S3). This work was partially carried out using research equipment shared within the MEXT Project ‘Promoting Public Utilization of Advanced Research Infrastructure’ (program for the supporting construction of core facilities) under grant JPMXS0440400023.
Supported by: Japan Society for the Promotion of Science 22K05116 ,25K00077
Abstract
Allylation reactions are essential for the introduction of alkene functionalities into molecules, and radical allylation reactions serve as a powerful strategy to achieve this. Of the various known allylating reagents, allyl bromides offer a particularly direct and efficient approach to allylation. In this study, we report the radical allylation of vinyl perfluorocyclic sulfonamides using allyl bromides, leading to the synthesis of allylated fluoroalkyl sulfonamides.
Publication History
Received: 17 October 2025
Accepted after revision: 29 November 2025
Accepted Manuscript online:
29 November 2025
Article published online:
17 December 2025
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