Reductive Amination - A Convenient Method for Generating Diverse, Mono-Functionalised 5,10,15,20-Tetraphenyl Porphyrins

Abstract

Formylation followed by reductive amination of 5,10,15,20-tetraphenyl porphyrin (TPP) is shown to be a versatile synthetic procedure for monosubstitution of the porphyrin core regiospecifically at one β-position. A diverse range of substituents can be introduced in this way in good yields, including cyclen aza-crown macrocycles.

Key words

porphyrin - substitution - cyclen - amination - regioselective

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