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Synthesis 2009(5): 710-712
DOI: 10.1055/s-0028-1083367
DOI: 10.1055/s-0028-1083367
SHORTPAPER
© Georg Thieme Verlag
Stuttgart ˙ New York
Synthesis of d/l-erythro-Sphingosine Using a Tethered Aminohydroxylation Reaction as the Key Step
Further Information
Received
14 July 2008
Publication Date:
11 February 2009 (online)
Publication History
Publication Date:
11 February 2009 (online)
Abstract
A diastereoselective synthesis of racemic d/l-erythro-sphingosine is described. The approach involves employing tethered aminohydroxylation (TA) to introduce the 2-amino and 3-hydroxy functions with required stereochemistry.
Key words
sphingolipids - sphingosine - ceramide - amino alcohols - diasteroselectivity
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